Epigenetic silencing of CHD5, a novel tumor suppressor gene, occurs in early colorectal cancer stages

BACKGROUND: The chromodomain helicase DNA binding protein 5 (CHD5) is a family member of chromatin remodeling factors. The epigenetic silencing mechanisms of CHD5 in colorectal cancer (CRC) has not been well studied. METHODS: Here we analyzed the CHD5 methylation and mRNA expression in vitro and in...

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Bibliographic Details
Main Authors: Fatemi, Mehrnaz, Paul, Thomas A., Brodeur, Garrett M., Shokrani, Babak, Brim, Hassan, Ashktorab, Hassan
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947327/
https://ncbi.nlm.nih.gov/pubmed/24243398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28316
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