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Combination of Sunitinib with anti-tumor vaccination inhibits T cell priming and requires careful scheduling to achieve productive immunotherapy

Sunitinib, a protein tyrosine kinase inhibitor is the frontline therapy for renal and gastrointestinal cancers. We hypothesized that by virtue of its well documented tumor apoptosis and immune adjuvant properties, combination of Sunitinib with anti-tumor immunotherapeutics will provide synergistic i...

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Detalhes bibliográficos
Main Authors: Jaini, Ritika, Rayman, Patricia, Cohen, Peter A., Finke, James H., Tuohy, Vincent K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947113/
https://ncbi.nlm.nih.gov/pubmed/24105638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.28488
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