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Lipid Modulation of Calcium Flux through Ca(V)2.3 Regulates Acrosome Exocytosis and Fertilization

Membrane lipid regulation of cell function is poorly understood. In early development, sterol efflux and the ganglioside G(M1) regulate sperm acrosome exocytosis (AE) and fertilization competence through unknown mechanisms. Here, we show that sterol efflux and focal enrichment of G(M1) trigger Ca(2+...

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Autors principals: Cohen, Roy, Buttke, Danielle E., Asano, Atsushi, Mukai, Chinatsu, Nelson, Jacquelyn L., Ren, Dongjun, Miller, Richard, Cohen-Kutner, Moshe, Atlas, Daphne, Travis, Alexander J.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947087/
https://ncbi.nlm.nih.gov/pubmed/24525187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.01.005
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