In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.

It is proposed that the CDK7-cyclin H complex functions in cell cycle progression, basal transcription and DNA repair. Here we report that in vitro reconstitution of an active CDK7-cyclin H complex requires stoichiometric amounts of a novel 36 kDa assembly factor termed MAT1 (ménage à trois 1). Sequ...

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Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Tassan, J P, Jaquenoud, M, Fry, A M, Frutiger, S, Hughes, G J, Nigg, E A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1995
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394676/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8521818/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb00248.x
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