C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.

Critical loci for ion conduction in inward rectifier K+ channels are only now being discovered. The C-terminal region of IRK1 plays a crucial role in Mg2+i blockade and single-channel K+ conductance. A negatively charged aspartate in the putative second transmembrane domain (position 172) is essenti...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Taglialatela, M, Ficker, E, Wible, B A, Brown, A M
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394667/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8521810/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb00240.x
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