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Design Rules for Selective Binding of Nuclear Localization Signals to Minor Site of Importin α

Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The...

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書目詳細資料
Main Authors: Pang, Xiaodong, Zhou, Huan-Xiang
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946659/
https://ncbi.nlm.nih.gov/pubmed/24609064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091025
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