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Circulating Complexes of the Vitamin D Binding Protein with G-Actin Induce Lung Inflammation by Targeting Endothelial Cells

This study investigated the actin scavenger function of the vitamin D binding protein (DBP) in vivo using DBP null (−/−) mice. Intravenous injection of G-actin into wild-type (DBP+/+) and DBP−/− mice showed that contrary to expectations, DBP+/+ mice developed more severe acute lung inflammation. Inf...

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Bibliografiske detaljer
Main Authors: Ge, Lingyin, Trujillo, Glenda, Miller, Edmund J., Kew, Richard R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946638/
https://ncbi.nlm.nih.gov/pubmed/24268110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imbio.2013.10.001
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