Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation.

A linear mammalian artificial chromosome vector will require at least three functional elements: a centromere, two telomeres and replication origins. One route to generate such a vector is by the fragmentation of an existing chromosome. We have previously described the use of cloned telomeric DNA to...

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Main Authors: Farr, C J, Bayne, R A, Kipling, D, Mills, W, Critcher, R, Cooke, H J
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC394653/
https://ncbi.nlm.nih.gov/pubmed/7489733
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