Human Leukocyte Antigen Genes and Interferon Beta Preparations Influence Risk of Developing Neutralizing Anti-Drug Antibodies in Multiple Sclerosis

A significant proportion of patients with multiple sclerosis who receive interferon beta (IFNβ) therapy develop neutralizing antibodies (NAbs) that reduce drug efficacy. To investigate if HLA class I and II alleles are associated with development of NAbs against IFNβ we analyzed whether NAb status a...

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Autores principales: Link, Jenny, Lundkvist Ryner, Malin, Fink, Katharina, Hermanrud, Christina, Lima, Izaura, Brynedal, Boel, Kockum, Ingrid, Hillert, Jan, Fogdell-Hahn, Anna
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946519/
https://ncbi.nlm.nih.gov/pubmed/24608124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090479
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