PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria

Cerebral malaria (CM) is associated with a high mortality rate, and long-term neurocognitive impairment in approximately one third of survivors. Adjunctive therapies that modify the pathophysiological processes involved in CM may improve outcome over anti-malarial therapy alone. PPARγ agonists have...

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Main Authors: Serghides, Lena, McDonald, Chloe R., Lu, Ziyue, Friedel, Miriam, Cui, Cheryl, Ho, Keith T., Mount, Howard T. J., Sled, John G., Kain, Kevin C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946361/
https://ncbi.nlm.nih.gov/pubmed/24603727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003980
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