Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients

BACKGROUND: ApoE4 has been associated with an increased risk of Alzheimer’s disease (AD), amyloid deposition and hypometabolism. ApoE4 is less prevalent in non-amnestic AD variants suggesting a direct effect on the clinical phenotype. However, the impact of ApoE4 on amyloid burden and glucose metabo...

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Main Authors: Lehmann, Manja, Ghosh, Pia M., Madison, Cindee, Karydas, Anna, Coppola, Giovanni, O’Neil, James P., Huang, Yadong, Miller, Bruce L., Jagust, William J., Rabinovici, Gil D.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946299/
https://ncbi.nlm.nih.gov/pubmed/23965289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2013-305858
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