5-Azacytidine Improves the Osteogenic Differentiation Potential of Aged Human Adipose-Derived Mesenchymal Stem Cells by DNA Demethylation

The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is critically discussed. A possible reason for reduced osteogenic potential may be an age-related deterioration of the Ad-MSCs. In long term in vitro culture, epigenomic changes in DNA methylation are kno...

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Detalhes bibliográficos
Main Authors: Yan, Xueying, Ehnert, Sabrina, Culmes, Mihaela, Bachmann, Anastasia, Seeliger, Claudine, Schyschka, Lilianna, Wang, Zhiyong, Rahmanian-Schwarz, Afshin, Stöckle, Ulrich, De Sousa, Paul A., Pelisek, Jaroslav, Nussler, Andreas K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946260/
https://ncbi.nlm.nih.gov/pubmed/24603866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090846
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