High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells

It remains controversial whether the abnormal epigenetic modifications accumulated in the induced pluripotent stem cells (iPSCs) can ultimately affect iPSC pluripotency. To probe this question, iPSC lines with the same genetic background and proviral integration sites were established, and the pluri...

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Hauptverfasser: Chang, Gang, Gao, Shuai, Hou, Xinfeng, Xu, Zijian, Liu, Yanfeng, Kang, Lan, Tao, Yu, Liu, Wenqiang, Huang, Bo, Kou, Xiaochen, Chen, Jiayu, An, Lei, Miao, Kai, Di, Keqian, Wang, Zhilong, Tan, Kun, Cheng, Tao, Cai, Tao, Gao, Shaorong, Tian, Jianhui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945885/
https://ncbi.nlm.nih.gov/pubmed/24381111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.173
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