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Gene regulation by PAX6: Structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204

PURPOSE: Pax6 is a key regulatory gene for eye, brain, and pancreas development. It acts as a transcriptional activator and repressor. Loss-of-function of Pax6 results in down- and upregulation of a comparable number of genes, although many are secondary targets. Recently, we found a prototype of a...

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Main Authors: Xie, Qing, Ung, Devina, Khafizov, Kamil, Fiser, Andras, Cvekl, Ales
Format: Artigo
Jezik:Inglês
Izdano: Molecular Vision 2014
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945805/
https://ncbi.nlm.nih.gov/pubmed/24623969
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