Transcriptional Repression of the Transforming Growth Factor β (TGF-β) Pseudoreceptor BMP and Activin Membrane-bound Inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 Enhances TGF-β Signaling in Hepatic Stellate Cells

TLR4 signaling induces down-regulation of the bone morphogenic protein (BMP) and activin membrane-bound inhibitor (BAMBI), which enhances TGF-β signaling during hepatic stellate cell (HSC) activation. We investigated the mechanism by which TLR4 signaling down-regulates BAMBI expression in HSCs and f...

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Detalhes bibliográficos
Main Authors: Liu, Cheng, Chen, Xiaorong, Yang, Ling, Kisseleva, Tatiana, Brenner, David A., Seki, Ekihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945368/
https://ncbi.nlm.nih.gov/pubmed/24448807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.543769
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