LT175 Is a Novel PPARα/γ Ligand with Potent Insulin-sensitizing Effects and Reduced Adipogenic Properties

Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors regulating lipid and glucose metabolism. Ongoing drug discovery programs aim to develop dual PPARα/γ agonists devoid of the side effects of the marketed antidiabetic agents thiazolidinediones and the dual...

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Autori principali: Gilardi, Federica, Giudici, Marco, Mitro, Nico, Maschi, Omar, Guerrini, Uliano, Rando, Gianpaolo, Maggi, Adriana, Cermenati, Gaia, Laghezza, Antonio, Loiodice, Fulvio, Pochetti, Giorgio, Lavecchia, Antonio, Caruso, Donatella, De Fabiani, Emma, Bamberg, Krister, Crestani, Maurizio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945352/
https://ncbi.nlm.nih.gov/pubmed/24451380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.506394
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