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Dysregulated Estrogen Receptor Signaling in the Hypothalamic-Pituitary-Ovarian Axis Leads to Ovarian Epithelial Tumorigenesis in Mice

The etiology of ovarian epithelial cancer is poorly understood, mainly due to the lack of an appropriate experimental model for studying the onset and progression of this disease. We have created a mutant mouse model in which aberrant estrogen receptor alpha (ERα) signaling in the hypothalamic-pitui...

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Main Authors: Laws, Mary J., Kannan, Athilakshmi, Pawar, Sandeep, Haschek, Wanda M., Bagchi, Milan K., Bagchi, Indrani C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945209/
https://ncbi.nlm.nih.gov/pubmed/24603706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004230
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