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Axonal Transport: How High Microtubule Density Can Compensate for Boundary Effects in Small-Caliber Axons

Long-distance intracellular axonal transport is predominantly microtubule-based, and its impairment is linked to neurodegeneration. In this study, we present theoretical arguments that suggest that near the axon boundaries (walls), the effective viscosity can become large enough to impede cargo tran...

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Detalhes bibliográficos
Main Authors: Wortman, Juliana C., Shrestha, Uttam M., Barry, Devin M., Garcia, Michael L., Gross, Steven P., Yu, Clare C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944719/
https://ncbi.nlm.nih.gov/pubmed/24559984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.12.047
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