Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma

PURPOSE: To elucidate the mechanistic basis for efficacy of intrathecal rituximab. We evaluated complement activation as well as the pharmacokinetics of intraventricular rituximab in patients who participated in two phase 1 multicenter studies. EXPERIMENTAL DESIGN: We evaluated complement activation...

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Bibliografiske detaljer
Main Authors: Kadoch, Cigall, Li, Jing, Wong, Valerie S., Chen, Lingjing, Cha, Soonmee, Munster, Pamela, Lowell, Clifford A., Shuman, Marc A., Rubenstein, James L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944388/
https://ncbi.nlm.nih.gov/pubmed/24190981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0474
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