Effective Intravenous Therapy for Neurodegenerative Disease With a Therapeutic Enzyme and a Peptide That Mediates Delivery to the Brain

The blood–brain barrier (BBB) presents a major challenge to effective treatment of neurological disorders, including lysosomal storage diseases (LSDs), which frequently present with life-shortening and untreatable neurodegeneration. There is considerable interest in methods for intravenous delivery...

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Detalhes bibliográficos
Main Authors: Meng, Yu, Sohar, Istvan, Sleat, David E, Richardson, Jason R, Reuhl, Kenneth R, Jenkins, Robert B, Sarkar, Gobinda, Lobel, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944336/
https://ncbi.nlm.nih.gov/pubmed/24394185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.267
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