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Diversity-oriented synthesis of dihydrobenzoxazepinones by coupling the Ugi multicomponent reaction with a Mitsunobu cyclization

An operationally simple protocol for the synthesis of 2,3-dihydrobenzo[f][1,4]oxazepin-3-ones, based on an Ugi reaction of an ortho-(benzyloxy)benzylamine, glycolic acid, an isocyanide and an aldehyde, followed by an intramolecular Mitsunobu substitution was developed. The required ortho-(benzyloxy)...

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Bibliografiske detaljer
Main Authors: Moni, Lisa, Banfi, Luca, Basso, Andrea, Brambilla, Alice, Riva, Renata
Format: Artigo
Sprog:Inglês
Udgivet: Beilstein-Institut 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943941/
https://ncbi.nlm.nih.gov/pubmed/24605140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.10.16
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