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8-Oxoguanine DNA glycosylase-1 augments pro-inflammatory gene expression by facilitating the recruitment of site-specific transcription factors
Among the insidious DNA base lesions, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant, a lesion that arises through the attack by reactive oxygen species on guanine, especially when located in cis-regulatory elements. 8-oxoG is repaired by the 8-oxoguanine glycosylase 1 (OGG1)-initiate...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3943862/ https://ncbi.nlm.nih.gov/pubmed/24489103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302472 |
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