Deletion of SIRT1 from Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty liver

BACKGROUND&AIMS: Sirtuin (SIRT1) is a NAD(+)-dependent protein deacetylase that regulates hepatic lipid metabolism by modifying histones and transcription factors. Ethanol exposure disrupts SIRT1 activity and contributes to alcoholic liver disease (ALD) in rodents, but the exact pathogenic mecha...

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Detalhes bibliográficos
Main Authors: Yin, Huquan, Hu, Ming, Liang, Xiaomei, Ajmo, Joanne M., Li, Xiaoling, Bataller, Ramon, Odena, Gemma, Stevens, Stanley M., You, Min
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943758/
https://ncbi.nlm.nih.gov/pubmed/24262277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.11.008
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