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Exploiting Cell-To-Cell Variability To Detect Cellular Perturbations

Any single-cell-resolved measurement generates a population distribution of phenotypes, characterized by a mean, a variance, and a shape. Here we show that changes in the shape of a phenotypic distribution can signal perturbations to cellular processes, providing a way to screen for underlying molec...

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Bibliografiske detaljer
Main Authors: Dey, Gautam, Gupta, Gagan D., Ramalingam, Balaji, Sathe, Mugdha, Mayor, Satyajit, Thattai, Mukund
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942435/
https://ncbi.nlm.nih.gov/pubmed/24594940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090540
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