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Exploiting Cell-To-Cell Variability To Detect Cellular Perturbations
Any single-cell-resolved measurement generates a population distribution of phenotypes, characterized by a mean, a variance, and a shape. Here we show that changes in the shape of a phenotypic distribution can signal perturbations to cellular processes, providing a way to screen for underlying molec...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3942435/ https://ncbi.nlm.nih.gov/pubmed/24594940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090540 |
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