Maximizing power to track Alzheimer’s disease and MCI progression by LDA-based weighting of longitudinal ventricular surface features

We propose a new method to maximize biomarker efficiency for detecting anatomical change over time in serial MRI. Drug trials using neuroimaging become prohibitively costly if vast numbers of subjects must be assessed, so it is vital to develop efficient measures of brain change. A popular measure o...

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Main Authors: Gutman, Boris A., Hua, Xue, Rajagopalan, Priya, Chou, Yi-Yu, Wang, Yalin, Yanovsky, Igor, Toga, Arthur W., Jack, Clifford R., Weiner, Michael W., Thompson, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942253/
https://ncbi.nlm.nih.gov/pubmed/23296188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2012.12.052
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