Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice

BACKGROUND: Transforming growth factor (TGF)-β1 produced in airway epithelia has been suggested as a contributor to the airway remodeling observed in asthma patients. The protein tyrosine phosphatase SHP2 is a demonstrable modulator of TGF-β1 production and thus a potential regulator of airway remod...

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Hlavní autoři: Qin, X.-J., Zhang, G.-S., Zhang, X., Qiu, Z.-W., Wang, P.-L., Li, Y.-W., Li, W., Xie, Q.-M., Ke, Y.-H., Lee, J. J., Shen, H.-H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942166/
https://ncbi.nlm.nih.gov/pubmed/23057634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.12048
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