Accelerating clinical development of HIV vaccine strategies: methodological challenges and considerations in constructing an optimised multi-arm phase I/II trial design

BACKGROUND: Many candidate vaccine strategies against human immunodeficiency virus (HIV) infection are under study, but their clinical development is lengthy and iterative. To accelerate HIV vaccine development optimised trial designs are needed. We propose a randomised multi-arm phase I/II design f...

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Hlavní autoři: Richert, Laura, Doussau, Adélaïde, Lelièvre, Jean-Daniel, Arnold, Vincent, Rieux, Véronique, Bouakane, Amel, Lévy, Yves, Chêne, Geneviève, Thiébaut, Rodolphe
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Methodology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941694/
https://ncbi.nlm.nih.gov/pubmed/24571662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-15-68
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