Accelerating clinical development of HIV vaccine strategies: methodological challenges and considerations in constructing an optimised multi-arm phase I/II trial design

BACKGROUND: Many candidate vaccine strategies against human immunodeficiency virus (HIV) infection are under study, but their clinical development is lengthy and iterative. To accelerate HIV vaccine development optimised trial designs are needed. We propose a randomised multi-arm phase I/II design f...

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Detalhes bibliográficos
Main Authors: Richert, Laura, Doussau, Adélaïde, Lelièvre, Jean-Daniel, Arnold, Vincent, Rieux, Véronique, Bouakane, Amel, Lévy, Yves, Chêne, Geneviève, Thiébaut, Rodolphe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941694/
https://ncbi.nlm.nih.gov/pubmed/24571662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-15-68
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