Chromatin differentiation of white blood cells decreases DSB damage induction, prevents functional assembly of repair foci, but has no influence on protrusion of heterochromatic DSBs into the low-dense chromatin

Purpose: Higher order chromatin structure progressively changes with cell differentiation and seems to play an important role in DNA double-strand break (DSB) induction and repair (reviewed in [1]). We compared DNA damage in heterochromatin (Hc) upon the action of qualitatively different radiations....

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Detalhes bibliográficos
Main Authors: Falk, Martin, Lukasova, Emilie, Falkova, Iva, Stefancikova, Lenka, Jezkova, Lucie, Bacikova, Alena, Davídková, Marie, Boreyko, Alla, Krasavin, Evgeny A., Kozubek, Stanislav
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Poster Session 01: DNA Damage and Repair
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941545/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rrt194
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