Live Multicellular Tumor Spheroid Models For High-Content Imaging and Screening In Cancer Drug Discovery

The multi cellular tumor spheroid (MCTS) model has been used for decades with proven superiority over monolayer cell culture models at recapitulating in vivo tumor growth. Yet its use in high-throughput drug discovery has been limited, particularly with image based screening, due to practical and te...

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Bibliografiske detaljer
Main Authors: Reid, Brian G., Jerjian, Taleen, Patel, Purvi, Zhou, Qiong, Yoo, Byong Hoon, Kabos, Peter, Sartorius, Carol A., LaBarbera, Daniel V.
Format: Artigo
Sprog:Inglês
Udgivet: Bentham Open 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941083/
https://ncbi.nlm.nih.gov/pubmed/24596682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/2213988501408010027
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