Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2

Despite the well-documented clinical significance of the Warburg effect, it remains unclear how the aggressive glycolytic rates of tumor cells might contribute to other hallmarks of cancer, such as bypass of senescence. Here, we report that, during oncogene- or DNA damage–induced senescence, Pak1-me...

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Detalhes bibliográficos
Main Authors: Mikawa, Takumi, Maruyama, Takeshi, Okamoto, Koji, Nakagama, Hitoshi, Lleonart, Matilde E., Tsusaka, Takeshi, Hori, Kousuke, Murakami, Itsuo, Izumi, Taisuke, Takaori-Kondo, Akifumi, Yokode, Masayuki, Peters, Gordon, Beach, David, Kondoh, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941061/
https://ncbi.nlm.nih.gov/pubmed/24567357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201306149
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