Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2

Despite the well-documented clinical significance of the Warburg effect, it remains unclear how the aggressive glycolytic rates of tumor cells might contribute to other hallmarks of cancer, such as bypass of senescence. Here, we report that, during oncogene- or DNA damage–induced senescence, Pak1-me...

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Bibliografiske detaljer
Main Authors: Mikawa, Takumi, Maruyama, Takeshi, Okamoto, Koji, Nakagama, Hitoshi, Lleonart, Matilde E., Tsusaka, Takeshi, Hori, Kousuke, Murakami, Itsuo, Izumi, Taisuke, Takaori-Kondo, Akifumi, Yokode, Masayuki, Peters, Gordon, Beach, David, Kondoh, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941061/
https://ncbi.nlm.nih.gov/pubmed/24567357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201306149
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