Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2

Despite the well-documented clinical significance of the Warburg effect, it remains unclear how the aggressive glycolytic rates of tumor cells might contribute to other hallmarks of cancer, such as bypass of senescence. Here, we report that, during oncogene- or DNA damage–induced senescence, Pak1-me...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Mikawa, Takumi, Maruyama, Takeshi, Okamoto, Koji, Nakagama, Hitoshi, Lleonart, Matilde E., Tsusaka, Takeshi, Hori, Kousuke, Murakami, Itsuo, Izumi, Taisuke, Takaori-Kondo, Akifumi, Yokode, Masayuki, Peters, Gordon, Beach, David, Kondoh, Hiroshi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2014
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941061/
https://ncbi.nlm.nih.gov/pubmed/24567357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201306149
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