BRAF(V600E) Mutation and Its Association with Clinicopathological Features of Colorectal Cancer: A Systematic Review and Meta-Analysis

BACKGROUND: Colorectal cancer (CRC) is a heterogeneous disease with multiple underlying causative genetic mutations. The B-type Raf proto-oncogene (BRAF) plays an important role in the mitogen-activated protein kinase (MAPK) signaling cascade during CRC. The presence of BRAF(V600E) mutation can dete...

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Main Authors: Chen, Dong, Huang, Jun-Fu, Liu, Kai, Zhang, Li-Qun, Yang, Zhao, Chuai, Zheng-Ran, Wang, Yun-Xia, Shi, Da-Chuan, Huang, Qing, Fu, Wei-Ling
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940924/
https://ncbi.nlm.nih.gov/pubmed/24594804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090607
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