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New Insights into Transcription Fidelity: Thermal Stability of Non-Canonical Structures in Template DNA Regulates Transcriptional Arrest, Pause, and Slippage

The thermal stability and topology of non-canonical structures of G-quadruplexes and hairpins in template DNA were investigated, and the effect of non-canonical structures on transcription fidelity was evaluated quantitatively. We designed ten template DNAs: A linear sequence that does not have sign...

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Bibliografiske detaljer
Main Authors: Tateishi-Karimata, Hisae, Isono, Noburu, Sugimoto, Naoki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940900/
https://ncbi.nlm.nih.gov/pubmed/24594642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090580
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