Sphingosine Kinase 1 Promotes Malignant Progression in Colon Cancer and Independently Predicts Survival of Patients With Colon Cancer by Competing Risk Approach in South Asian Population

OBJECTIVES: Sphingosine kinase 1 (SphK1) phosphorylates the membrane sphingolipid, sphingosine, to sphingosine-1-phosphate (S1P), an oncogenic mediator, which drives tumor cell growth and survival. Although SphK1 has gained increasing prominence as an oncogenic determinant in several cancers, its po...

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Bibliographic Details
Main Authors: Tan, Sheryl S L, Khin, Lay W, Wong, Lingkai, Yan, Benedict, Ong, Chee W, Datta, Arpita, Salto-Tellez, Manuel, Lam, Yulin, Yap, Celestial T
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
Subjects:
Colon/Small Bowel
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940836/
https://ncbi.nlm.nih.gov/pubmed/24572701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ctg.2013.21
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