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Clusters of point mutations are found exclusively around rearranged antibody variable genes.
We have examined the nucleotide sequences of a series of murine antibody genes derived from one kappa light chain gene in order to gain insight into the mechanism that specifically mutates variable genes. Six rearranged VK167 genes from hybridoma and myeloma cells were cloned from bacteriophage lamb...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1983
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394059/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6222379/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.11.3439 |
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