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Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity.
The biochemical basis for bleomycin-induced pulmonary toxicity was studied in vitro and in vivo with an improved HPLC system. The in vitro metabolism of bleomycin A2 to desamido-bleomycin A2 was measured in tissue homogenates from a species sensitive (mice) and relatively resistant (rabbits) to the...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1983
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393974/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6190169/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.10.3064 |
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