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Multidrug Resistance: Physiological Principles and Nanomedical Solutions

Multidrug (MDR) resistance is a pathophysiological phenomenon employed by cancer cells which limits the prolonged and effective use of chemotherapeutic agents. MDR is primarily based on the over-expression of drug efflux pumps in the cellular membrane. Prominent examples of such efflux pumps, which...

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Main Authors: Kunjachan, Sijumon, Rychlik, Błażej, Storm, Gert, Kiessling, Fabian, Lammers, Twan
格式: Artigo
語言:Inglês
出版: 2013
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939439/
https://ncbi.nlm.nih.gov/pubmed/24120954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2013.09.018
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