An evolutionary ratchet leading to loss of elongation factors in eukaryotes

BACKGROUND: The GTPase eEF1A is the eukaryotic factor responsible for the essential, universal function of aminoacyl-tRNA delivery to the ribosome. Surprisingly, eEF1A is not universally present in eukaryotes, being replaced by the paralog EFL independently in multiple lineages. The driving force be...

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Hauptverfasser: Atkinson, Gemma C, Kuzmenko, Anton, Chicherin, Ivan, Soosaar, Axel, Tenson, Tanel, Carr, Martin, Kamenski, Piotr, Hauryliuk, Vasili
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938643/
https://ncbi.nlm.nih.gov/pubmed/24564225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-14-35
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