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Dicing with chance, life and death in systematic reviews and meta-analyses: D.I.C.E. 3, a simulation study

OBJECTIVES: To show the effects of chance on meta-analyses, and the potential dangers of being prompted to do a meta-analysis by one favourable trial. DESIGN: In total, 100,000 trials were simulated and combined into 10,000 meta-analyses, using data from the control group of a cancer trial. Each par...

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Bibliografiske detaljer
Main Authors: Clarke, Mike, Halsey, Jim
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938124/
https://ncbi.nlm.nih.gov/pubmed/24526461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0141076813514574
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