Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

Leishmania tropica promastigotes that are highly resistant to methotrexate, a dihydrofolate reductase inhibitor, have been developed. Organisms resistant to 1 mM methotrexate have a 40-fold increase in dihydrofolate reductase which is associated with thymidylate synthetase, and they contain amplifie...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Coderre, J A, Beverley, S M, Schimke, R T, Santi, D V
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1983
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393771/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6572966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.8.2132
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