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3′ end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells

3′ end formation of pre-mRNAs is coupled to their transcription via the C-terminal domain (CTD) of RNA polymerase II (Pol II). Nearly all protein-coding transcripts are matured by cleavage and polyadenylation (CPA), which is frequently misregulated in disease. Understanding how transcription is coor...

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Autori principali: Davidson, Lee, Muniz, Lisa, West, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937513/
https://ncbi.nlm.nih.gov/pubmed/24478330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.231274.113
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