TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways

BACKGROUND: Transforming growth factor-β (TGF-β) is a key cytokine during differentiation of mesenchymal stem cells (MSC) into vascular smooth muscle cells (VSMC). High phosphate induces a phenotypic transformation of vascular smooth muscle cells (VSMC) into osteogenic-like cells. This study was aim...

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Main Authors: Guerrero, Fátima, Herencia, Carmen, Almadén, Yolanda, Martínez-Moreno, Julio M., Montes de Oca, Addy, Rodriguez-Ortiz, María Encarnación, Diaz-Tocados, Juan M., Canalejo, Antonio, Florio, Mónica, López, Ignacio, Richards, William G., Rodriguez, Mariano, Aguilera-Tejero, Escolástico, Muñoz-Castañeda, Juan R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937350/
https://ncbi.nlm.nih.gov/pubmed/24586576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089179
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