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A Force-Based, Parallel Assay for the Quantification of Protein-DNA Interactions

Analysis of transcription factor binding to DNA sequences is of utmost importance to understand the intricate regulatory mechanisms that underlie gene expression. Several techniques exist that quantify DNA-protein affinity, but they are either very time-consuming or suffer from possible misinterpret...

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Detalhes bibliográficos
Main Authors: Limmer, Katja, Pippig, Diana A., Aschenbrenner, Daniela, Gaub, Hermann E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937344/
https://ncbi.nlm.nih.gov/pubmed/24586920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089626
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