Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages

BACKGROUND: Autophagy is a cellular response to intracellular pathogens including mycobacteria and is induced by the direct inhibitors of mammalian target of Rapamycin (mTOR), a major negative regulator of autophagy. Autophagy induction by mTOR inhibition (mTOR dependent autophagy), through chemical...

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Autores principales: Zullo, Alfred J, Jurcic Smith, Kristen L, Lee, Sunhee
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937017/
https://ncbi.nlm.nih.gov/pubmed/24528777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-15-4
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