Differences in virulence of pneumolysin and autolysin mutants constructed by insertion duplication mutagenesis and in-frame deletion in Streptococcus pneumoniae

BACKGROUND: Insertion duplication mutagenesis (IDM) and in-frame deletion (IFD) are common techniques for studying gene function, and have been applied to pneumolysin (ply), a virulence gene in Streptococcus pneumoniae (D39). Discrepancies in virulence between the two techniques were observed in bot...

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Bibliographic Details
Main Authors: Liu, Esther Yip-Mei, Chang, Feng-Yee, Chang, Jen-Chang, Fung, Chang-Phone
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936844/
https://ncbi.nlm.nih.gov/pubmed/24558977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-14-16
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