Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses

Aims: The free radical scavenger and nitric oxide synthase cofactor, 5,6,7,8-tetrahydrobiopterin (BH4), plays a well-documented role in many disorders associated with oxidative stress, including normal tissue radiation responses. Radiation exposure is associated with decreased BH4 levels, while BH4...

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Detalhes bibliográficos
Main Authors: Pathak, Rupak, Pawar, Snehalata A., Fu, Qiang, Gupta, Prem K., Berbée, Maaike, Garg, Sarita, Sridharan, Vijayalakshmi, Wang, Wenze, Biju, Prabath G., Krager, Kimberly J., Boerma, Marjan, Ghosh, Sanchita P., Cheema, Amrita K., Hendrickson, Howard P., Aykin-Burns, Nukhet, Hauer-Jensen, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Forum Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936502/
https://ncbi.nlm.nih.gov/pubmed/23521531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.5025
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