Trehalose Reverses Cell Malfunction in Fibroblasts from Normal and Huntington's Disease Patients Caused by Proteosome Inhibition

Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive and psychiatric deficits, associated with predominant loss of striatal neurons and is caused by polyglutamine expansion in the huntingtin protein. Mutant huntingtin protein and its fragments...

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Main Authors: Fernandez-Estevez, Maria Angeles, Casarejos, Maria Jose, López Sendon, Jose, Garcia Caldentey, Juan, Ruiz, Carolina, Gomez, Ana, Perucho, Juan, de Yebenes, Justo García, Mena, Maria Angeles
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934989/
https://ncbi.nlm.nih.gov/pubmed/24587280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090202
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