Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate

Ceramide is important for water retention and permeability barrier functions in the stratum corneum, and plays a key role in the pathogenesis of atopic dermatitis (AD). A Pseudomonas aeruginosa-derived neutral ceramidase (PaCDase) isolated from a patient with AD was shown to effectively degrade cera...

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Detalhes bibliográficos
Main Authors: Oizumi, Ami, Nakayama, Hitoshi, Okino, Nozomu, Iwahara, Chihiro, Kina, Katsunari, Matsumoto, Ryo, Ogawa, Hideoki, Takamori, Kenji, Ito, Makoto, Suga, Yasushi, Iwabuchi, Kazuhisa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934885/
https://ncbi.nlm.nih.gov/pubmed/24586752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089402
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