FMR1 Gray Zone Alleles: Association with Parkinson Disease in Women?

PURPOSE: Carriers of fragile X mental retardation 1 (FMR1) repeat expansions in the premutation range (55–200 CGG repeats), especially males, often develop tremor, ataxia, and parkinsonism.(1–2) These neurological signs are believed to be due to elevated levels of expanded CGG repeat FMR1 mRNA. The...

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Détails bibliographiques
Auteurs principaux: Hall, Deborah A, Berry-Kravis, Elizabeth, Zhang, Wenting, Tassone, Flora, Spector, Elaine, Zerbe, Gary, Hagerman, Paul J, Ouyang, Bichun, Leehey, Maureen A
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934001/
https://ncbi.nlm.nih.gov/pubmed/21567456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.23755
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