Building and Optimizing a Virus-specific T Cell Receptor Library for Targeted Immunotherapy in Viral Infections

Restoration of antigen-specific T cell immunity has the potential to clear persistent viral infection. T cell receptor (TCR) gene therapy can reconstitute CD8 T cell immunity in chronic patients. We cloned 10 virus-specific TCRs targeting 5 different viruses, causing chronic and acute infection. All...

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Main Authors: Banu, Nasirah, Chia, Adeline, Ho, Zi Zong, Garcia, Alfonso Tan, Paravasivam, Komathi, Grotenbreg, Gijsbert M., Bertoletti, Antonio, Gehring, Adam J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933865/
https://ncbi.nlm.nih.gov/pubmed/24566718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04166
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